I had a persistant problem where the CS6 trial of Photoshop crashed on 'Save As' under a new install of Mountain Lion.
After 3 days, and many re-installs, I tracked the problem down to 4 installed fonts, two of them Adobe font suitcases.
They are...
#PCmyoungjo.dfont
#Pilgiche.dfont
Adobe Sans MM
Adobe Serif MM
Removal of the above, which checked out fine using Font Book, also stopped my Office 11 suite from crashing on startup.
I had also removed every faulty font from my list of 2100+ fonts, and only when a clean install with the minimum of fonts worked, did I try dragging extra fonts in a few at a time, then, Bingo! Crashes.
CS6 worked fine under Lion with the full font list, so obviously something dramatic has changed in Mountain Lion regarding handling fonts.
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