I am having the same problem ... mine began after upgrading from 5.5 which I purchased a few weeks before v6 was announced.  I had the problem with a few programs in the suite but was able to iron out most of them (still having some challenges with Bridge and uploading new files into the program). Tech support was some help but was bit by bit rather than a solution  to the entire problem. It is INCREDIBLY frustrating ... the only time I can get help is via the phone support when I am supposed to be manning my own phones. If I didn't love the products so much, my credit card would be getting a call to terminate the purchase. This is a brand new machine, Adobe as one of the first and few set of installs/upgrades 5.5/6.0 ... when I talked to one of the Adobe reps at a trade show this week, he said there were a few cases where a new serial number was offered specific to Acrobat Pro due to the glitch. He is supposed to email me when he gets back to the office and has more info, but it has been frustrating.

Yes just had the same problem today (30 days after install of CS6) - followed Jimbo7777 advise of deactivating and then rebooting and opening Photoshop CS6 and entering the serial number. All works perfectly so thank you all

Have been dealing with this for a month now. At first deleting the cache.db file helped for a week or so. However, each time I do it the fix seems to last for less and less time. Now I have to do it every single day.

Ok, big thanks to William LeMartin but this solution is not professional support from the Adobe. We paid for legall app and we may expect more serious support.

I have exactly the same problem since upgrade from CS 5.5 to 6.0 on last July. Today I had to reinstall Acrobat and it is totally frustrating - over half a year and still no solution of the problem.

The same happened with CS6 here...

Well, there is a solution which worked for me. 

The Acrobat people have a patch and it's buried somewhere, a location I can't recal, and it's called "Acrofix.zip"

Wind-Dancer's link fixes it for us. Nice find, too bad there isn't a posted date on that fix.

This is so incredibly irritating. Patches didn't detect the need for this patch and the Application Manager did not either. Seems like this should be an automatic install. Then again the suite treats Acrobat as the oddball application, it doesn't even group it with the rest of the products.