Hi, Thomas. We'd like to help, but do need more information to do so.
Where is your file stored?
e.g. your Desktop, Documents folder, an external hard drive, network file share, etc.
Does this issue occur all of the time, or only sometimes?
What version of Dreamweaver are you using?
On what operating system, including version?
(e.g. Windows 7 64-bit Service Pack 1, Mac OS 10.6.8, etc.)
As a comparison test, please create a new file in Dreamweaver using one of the included layouts (e.g. 3-column liquid), save the file to your Desktop, and then make a change. Does the same issue occur with this file at all?
