To make sure the update successful, the Extension Manager CS6 GM build (220.127.116.112) or 6.0.1 update (18.104.22.168) should have been installed, and all files under the installation folder should be intact. There have been some users in this forum said that they failed to update EM to 6.0.1, most of them have deleted non-mother-tongue resource files from Extension Manager installation folder. If the version is not either of 22.214.171.1242 and 126.96.36.199 or you have deleted/modified some files, you will have to reinstall Extension Manager (from http://www.adobe.com/exchange/em_download/) then update it.
You can also generate log files to help troubleshooting, refer to http://forums.adobe.com/message/4431136#4431136 for details.
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