Same issue here. i select cancel and it appears to load okay. just an annoying message. one of many CS6 bugs.

thank you sir! worked like a charm.

Omke might have a different slant, but for me:

Software rendering userful if video card not powerful enough for certain functions, like slideshows.

Related to having more than one monitor.  But this is another issue I am a little fuzzy on.

Start Bridge at Login I can't recommend as you have to disable Bridge to update or to change to another version of Bridge.  Tricky to save changes you make in Bridge with the option also.

Keep 100% previews is useful if you want quicker full screen previews of images you have already built.  Takes up a lot more disk space in cache.

Also, can not recommend automatically export cache to folders as you still have central cache, and now have an additional cache in each folder.  Cache in folders can only be purged with Tools/cache/purge cache for xxx folder.  Useful if exporting files to another drive to make sure XMP file is transfered, but not necessary.

Check your disk space.  You should have 10 - 20% free.  Either too little space or you have some file that is corrupting the cache.  If you have any icons that show instead of a normal thumbnail look at it closely to see if it has a problem.

Omke might have a different slant, but for me:

Start Bridge at log in might be useful but having set this in the prefs automatically sets it to hide during start up. Therefor the benefit of having a Bridge ready to go with reading cache, thumbs and building criteria the first time is gone. When you select to activate Bridge for first use it still needs to to this and the only benefit was starting the application automatically. For this reason I set it myself in the system preferences without hiding. But truth to be told, Bridge still has a mind of its own and every now and then resets itself to hide at start up.

Using a 30 " inch Cinema display I have a huge Cache file for 1024 with Building Monitor sized previews set to on. However having the option to use the space bar and have a nice and sharp full screen is worth this effort.

I don't bother using Bridge as Digital Asset Management for my archive (often said, Canto Cumulus Single user does a far better job for this but does not have the features Bridge is good at) so I regularly (CS3 every 2 or 3 weeks because it was needed to get it to work again / CS6 once in a few month, depending on size) dump my whole cache file manual and restart Bridge holding down option key to start fresh again.

The export cache to folder provides a long standing bug on my system showing a window that Bridge can't read the Cache.T file, I agree with Curt, can't recommend this feature either.

But is your problem solved or do you still experience the screenshot as per your last post?

I continue to have the problem, tho the time consuming fix works for a little while.

The icon in your older screenshot points to CS6 but what are your machine specs and exact OSX and Bridge CS6 versions?

And do you use the disk maintenance to check and repair disk permissions every now and then?

It works for a few sessions, and then back to the problem.

Now sometimes cant even load any thumbs, folders, etc.

it's over.

Cant even use it anymore.  RIP