I'm having the exact same issue.  I've been on the phone with adobe for a week and they have been unsuccessful with fixing the problem.  Did you ever get it resolved.  If so, how????

I have the same problem with CS6 and have been on chat with adobe 3 times and on the phone for 4 more time and still did not get fix. Every 3 or 4 days the probelm re-occure. Very frustrating!!!

Hi Jeff,

Here is the case number: #0183595447 <https://www.adobe.com/cfusion/support/index.cfm?event=casedetail&id=01 83595447&loc=en_ca>

The support team had took control of my PC and try using a different admin account to change some security setting.

Thanks for checking into this, really appreciate your help!

They are obvious an oversea team that took a long time to even understand the problem

and don't seems to have the skill to resolve the issue and every time they keep promise me

that from now on it will not happens ever again. 2 days later. It happens again.

Then they call me at 6:30 am Calgary time to wake up my family.

Hi Jeff,

The version is 6.0.335.0

I do not know where to run CS6 with 32-bit.

I use the icon the installation of 64 bit put on the desktop.

Can you let me know where do I find the 32 bit exe?

Thanks!

Thanks Jeff, I'll try that and let you know if it works in a week see if it ask me to register again.

Appreciate your help!

Got the latest update version.

Tonight, the same problem happens again.

Follow the steps below.

Reboot PC.

Open CS6, ask me to activate again.

Still did not work

i never open with 32 bit.

Following your direction to open the 32 bit ps6.

It also asked me to activate.

Appears that it behave the same as the 64 bits.

After I activate the 32 bit cs6, the 64 bit also

Appear to be activated.

Sent from my iPad

Awesome Eisenray!  i removed the cache file as explained in the forum http://forums.adobe.com/thread/1070742 , had to re-enter my serial number one more time and now it seems to have accepted my serial number.  I have rebooted a couple times and each time my CS6 applications launch without asking for the serial number.  Interesting, my system is a new Dell and i purchased CS6 through Amazon, which seems to be a common factor in this problem.  Keeping my fingers crossed, but it looks good.  Thanks Eisenray and Jeff for the help.

Hello Jeff.

I am experiencing the same issue as Kongotech and the others.  Have you found any type of resolution?

Thanks,

Lit

Same here today is the 3rd day no problems so far. Lets hope that Adobe will find a fix for this issue soon.  

5th day and still problem so far its doing good after i removed C:\Program Files (x86)\Common Files\Adobe\Adobe PCD\cache\cache.db file   Its nice not to have to dig out the box each day and input a ser no#

Hello, I have been out for a few days, hoping a solution was available. So I opened up PS Sunday morning and same problem. I had deleted the cache file two times, but still I kept getting the request to license the software or start trial. I contacted Adobe using the Chat session. He asked that I re-name the cache file, so i did that. Of course it works for a while when I renamed the cache file and re-entered my serial number. The support person was convinced it was fixed, I had my doubts. Later that evening after updating all my adobe products and re-booting my system, launching PS, again i get the CS6 design standard trial window asking me to license the software or start the trial. I installed the software as Administrator, i have updated all of the applications, I have modified the permissions on the c:\Program Files(x86)\Common Files\Adobe\Adobe PCD\cache folder for everyone to have full control.  I thought this may have fixed it until i launched PS tonight (tuesday), and again i get the start trial prompt....

Looking at my cache folder permissions, it looks like it got changed back to their defaults again.  Not sure if this is the problem or not.  I will force the permissions to full control for everyone and try again.  Any help from Adobe on this would be GREAT!