Many users of the CS6 softwares complain about issues since their upgrade to CS6 with MAc OsX Lion 10.7.4 . For my part, I lost the use of my internal speaker and all videos in YouTube are soundless and freeze at 12 seconds. iTunes doesn't playback my mp3 but in Premiere, I 've got sound. I can't even adjust the volume of my speakers.
I have been running Lion (currently 10.7.4) for many months on an iMac and a MacBook Pro. In fact, Lion is about to be upgraded to Mountain Lion.
I have had no attributable problems when heavily running InDesign CS6, Illustrator CS6, Photoshop CS6 and other CS6 applications occasionallly.
Loss of internal speakers and ability to play YouTube videos may be Lion issues for you but it has nothing to do with Adobe. You might ask about those issues on the Apple Community Forums, or by visiting the Genius Bar at an Apple store.
OK, Adobe helped me and all you need to do is correctly uninstall older softwares prior to installing new ones. Here's the step by step: http://helpx.adobe.com/creative-suite/kb/cs5-cleaner-tool-installation -problems.html