I am runing Encore cs5.1 on a Mac Mountain Lion. Encore will not open. It gets hung up (not responding) I tried Cs4 yet had the same issue
The following may not be directly applicable to your OS or situation, but includes global issues and specifics. Look in particular at numbers 1 and 4.
Troubleshoot system errors and freezes | Adobe software on Mac OS 10.x
I don't do Mac, but I do have a few saved message links that may help
Mac and Root User http://forums.adobe.com/thread/879931
Mac & nVidia Driver http://forums.adobe.com/thread/1075592