I have had this problem so much I have switched back to using CS5 Photoshop when I handle layers. For some reason when I have a multi-layered photoshop file in CS6 and I try to save - it gives me a program error. This doesnt happen all the time just when I have been working on a document for a long length of time ( maybe something to do with auto save?) The only way I can save the file is to flatten but then I loose all of my hard work and layers! HELP!!
I did that but still experiencing the problem. If I wait too long to save a layered file ( hour or so ) that is when it seems to happen. Otherwise most other times I am able to save out a layered photoshop file. Other coworkers are experiencing it as well even after the update. Saving to desktop sometimes works, but it is hit or miss with different ways to save it out ( desktop, different name, large format file, layered tiff, click close on the file then it asks you if you want to save and I say yes and it saves...) If all options fail we are forced to just flatten and save a tiff and loose our layers.