If I open an pdf by Doubleclick i get the message "Test Writable APPDATA, Schreibzugriff verboten, Anwendung kann nicht ausgeführt werden".
If I close the message, Acrobat 10.1.4 opens.
If I open the document in Acrobat i have no problems.
New Installation of Acrobat didn´t help.
My System is Vista 32bit.
Then I don't understand where that message is coming from...
What I would try if this were happening to me is to update to 10.1.7; here are the patches
Sorry, I have no other ideas. The message makes no sense when you can actually write to that folder, so I am not sure if this is an Adobe Reader problem, or a problem with your folder structure.
P.S. one thing I would try if this were happening to me: run a CHKDSK on that disk with the /R option.