Mike & Jeff,
System Requirements for installation of Nikon Capture NX2 on Macintosh OS X (version 10.4.11 or 10.5.2) include a note that Capture NX2 is not compatible with the Case Sensitive, or Case Sensitive, Journaled disk formats.
Nikon is in the Adobe camp on this issue.
Adobe is just wrong on this. It's a huge failure on their part to require a case-insensitive drive. I feel cheated and ripped off. It's lazy poor programmers who program without strict adherence to case in filenames and variables. Shameful, and not that hard to fix.
I have hours invested in getting the software setup on my various Mac OSX Servers. Case sensitive filesystems are the default for the system disks, and something I choose routinely for all other drives. This is the proper filesystem. It's the RIGHT way do do things. All of my other software works EXCEPT Adobe products. I do not have the time or inclination to rebuild my system disk from scratch. It's cheaper for me to buy a new machine.
Wake up Adobe. WAKE UP! This is not a new issue. Support your users.