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in the change handler of your combobox you can create new instance of SupplierContent with the new selected supplier number.

private function changeHandler():void{

     var supplierContentObj:SupplierContent = new SupplierContent();

     this.addChild(supplierContentObj)

}

private function changeHandler():void{

     if(supplierContentObj){

          this.removeChild(supplierContentObj);

          supplierContentObj = null;

     }

     var supplierContentObj:SupplierContent = new SupplierContent();

     this.addChild(supplierContentObj);

}

Whenever a new instance of a component is created, the creationComplete event is dispatched. So, assuming that init() is the creationComplete eventHandler, this will also be called on every new instance creation.