not sure what you want to achieve, but it sounds like you could do the whole interactive element in HTML with Edge or Hype.
I you explain the whole user experience I might be able to help more
I'd like to create hyperlinks on specific words which give an explanation (popup) when you click them, like a legenda.
Some commercial websites use this method with advertisements, but I can't find one at the moment. Hope I made myself more clear
This isn't too hard.
Just select the text that acts like a hyperlink, open up the hyperlinks panel (window -> interactive -> hyperlinks) and click the "create new hyperlink" button.
Aaaaaaand you're done !
When you test this, you'll automatically have a pop-up to that specified website.
Thanks for your answer, but this isn't what I'm looking for. I don't want to point the hyperlink to a website, but to a pop-up which contains a local HTML-file (which contains an image and eventually some text), like a text-balloon.