Hi,
In a "standard" (i.e., no framework) CF application, I think
Application.cfc (for CF 7+) is an ideal location. If you're using a
framework (i.e., Fusebox, Model-Glue, ColdBox, etc.), the each
framework has their own locations that are ideal for this task.
I like Application.cfc because you can use the appropriate
method for scoping your variables. For example, the
onApplicationStart method is an excellent place to put your default
application-scoped variables.
Cheers,
Craig