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It look like we found the issue. It was sophos with it's application control. We had to turn off the on-access scanning for the application control policy. Now the PDFs open fine now.
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I installed LOGMEIN today and started getting the Fatal Errors:Acrobat failed to connect a DDE server. So, it is not just the Sophos or whatever the previous common denominator seemed to be. How do I fix this?
Thanks
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No solution I am afraid but same problem, running full version of AVG and problem hit immediately after Adobe Reader 9.1 upgrade. Pretty darn sure problem is in the upgrade but the relevant Restore Point was overwritten before I figured it out. Any advice welcome.