Select all topics in the Topics window.
Right click and select Properties.
In the Advanced tab, select a "Topic-level Tags" option
(Click "New" and assign a name for your tag).
If this will be a different layout (different from another
output that
includes that folder), right click the type of layout under
Single Source Layouts in the Project tab and click New.
In the first window of your Single Source Layout Properties
wizard, click "Define" in the Conditional Build Expression panel.
Select the build tag that will be excluded from your output.
Finish selecting options and save the layout.
Good luck,
Leon