I've got the same [edited by host] problem...
I've gone to the Windows Explorer Folders and the Files and DISABLED THE "READ ONLY" CHECK BOX ON EVERY LAST FILE & FOLDER REALTED TO IMAGES I'M ATTEMPTING TO EDIT...
BUT THEN IT RESETS THEM BACK TO BEING "READ ONLY" SEVERAL SECONDS LATER.
i'M THE ADMINISTRATOR ON THIS SYSTEM, NO QUESTION ABOUT IT...
I THINK IT'S ADOBE'S [edited by host] TOOLS....
ALSO THEIR HELP SECTION is poor [edited by host] TOO...
Host to poster: You have posted in the Photoshop Mac forum. As you are having a problem with your Windows system, then the a Windows forum would be a better place to post. Ranting at your fellow users is not likely to win you friends nor likely to encourage anyone to help you. This is a user to user forum and not a conduit to official Adobe technical support. Please be more civil in your future posts. These forums are visted by people of all ages. Foul-mouthed posting is not tolerated. Should you continue your posts in the same manner as this post, your posts will be deleted and you will be banned from the forums.
I'm having the exact same issue on my Mac. I have 12.0.1 x64.
When I reset all the preferences using Command-Option-Shift during launch, I was able to open Photoshop. The area in Preferences for the Scratch disc showed my primary drive twice in the list. Maybe this has something to do with it?
I exited out of the program, but it gives me the same error the next time I try to open Photoshop. So it looks like it's refusing to save or read my Preferences.
It could be that the permissions have gotten screwed up somewhere, but what file am I looking for? I have run a repair permissions from Disk Utility, so that all looks good.