Not that I know of, other than if you begin typing in the name of the CFC it should filter out the rest. Perhaps you can organize your CFCs in a way such that a single keystroke in there eliminates all of the CFCs you don't care about.
Hey, also check out this sentence and article on one of the Adobe Employee's blogs:
"ColdFusion Builder Extensions allow you to add filters to menu contributions . With this you can control what menus are visible/hidden when the context menu is displayed."
From a cursory glance, it looks like this may do what you want (in CF Builder 2 only??). Note Builder 2 was just beta released (http://labs.adobe.com/technologies/coldfusionbuilder2/). Let us know if it works.
You can use "Open CFC" toolbar item to quickly open the CFCs in current workspace. For more info refer http://blogs.adobe.com/cfbuilder/2009/07/open_cfc.html