Have the same problem.
dyld: Library not loaded: @rpath/iPhoneSimulatorRemoteClient.framework/Versions/A/iPhoneSimulatorRemoteClient
Referenced from: /Users/zh/Documents/flashResources/SDKs/4.6.0 + AIR 3.3b2/lib/aot/bin/isb/isb
Reason: image not found
/var/folders/dw/v8kcffb17fq4386ntnmw92540000gp/T/cmd2510539742407100497.tmp: line 1: 2050 Trace/BPT trap: 5 "/Users/zh/Documents/flashResources/SDKs/4.6.0 + AIR 3.3b2/lib/aot/bin/isb/isb" "-install" "-apppath" "/var/folders/dw/v8kcffb17fq4386ntnmw92540000gp/T/512b6309-2a2d-467d-a1cc-56687aab4f4c/Pa yload/test.app" "-sdkpath" "/Applications/Xcode.app/Contents/Developer/Platforms/iPhoneSimulator.platform/Developer/ SDKs/iPhoneSimulator5.1.sdk"
Zhizn, Flashlizi thanks for reporting your problem .
Its a known issue and fix would be available in next release .
However for the workaround you can install lower version of xcode say 3.2.6 on the machine .
This problem arises because Xcode in latest version installed as .app and we require mobile framework to be there in /developer directory.
Please try latest AIR 3.3 beta build form labs to resolve this problem
Also I have posted one blog regarding simulator support at http://blogs.adobe.com/airodynamics/2012/05/06/using-new-simulator-support-feature-for-ios /