Are you by chance trying to update the Acrobat.com Desktop Application? It's an Adobe AIR app we released a few years back.
If so, we recommend that you actually uninstall that application and access Acrobat.com by logging in here: http://acrobat.com/signin.html
We no longer support the Acrobat.com Desktop Application.
Please let me know if you have any questions.
If you're getting this error w/ Tweetdeck, it likely means that the update Tweetdeck is trying to install is incompatible with the AIR runtime you have installed. I'd suggest uninstalling Adobe AIR, then reinstalling from here: http://get.adobe.com/air/ Once you've reinstalled AIR, try launching Tweetdeck again to update.
I've got the latest version of Tweetdeck running w/ the latest version of AIR on both my Mac (10.6.8) and Windows (Win7) machines without issue.
Hope this helps!