Yes. You can manually edit the neo-datasource.xml file found in the cfusion/lib folder.
They will be listed individually in that file starting with:
<var name='DATASOURCE NAME'>
< then a series of <var> tags with the connection details>
You can just delete the one that is causing you issues. Also, there may be a neo-datasource.bak file in there with the original settings. Open that file and look to see if your offending datasource is in it. If not, rename it to neo-datasource.xml and rename the other to .old or something else. Restart Coldfusion and the new datasource information should be picked up.