First, if your host is any good at all, all the different
hosting clients are not strictly sharing CF.
The host should be using CF Enterprise and running each
client in their own instance.
Anyway, the application variables are controlled by the
cfapplication tag or by the Application.cfc name value.
On a given server instance, each application name has its own
Application scope.
Since a given set of files can only use one App tag or App
cfc, they can only have one Application scope.
Anyway, the values you want are NOT constant throughout the
application so they don't belong in the application scope per se.
Unless, maybe, you did something like this:
Application.UsrGroups[1].name = grunts
Application.UsrGroups[1].datasource = grunt_DB
Application.UsrGroups[2].name = Bosses
Application.UsrGroups[2].datasource = Boss_DB
etc.
But it is still probably cleaner to set the key values in the
Client scope.