Used the Adobe Updater today, 12/13/2012. Updated Photoshop CS6, inDesign CS6, Illustrator CS6, and some other stuff.
Once the update finished, I re-launched Illustrator CS6 to get some work done, and I was prompted to enter my serial number or continue with the Trial version. Odd. Same thing with any Adobe product that I had installed. Every application launch was intercepted and the Adobe Updater asked for my serial number.
Obviously I found and entered my serial number and everything is working fine now - BUT - the Adobe Updater should not be resetting or wiping out serial number information.
If this is a bug in the Adobe Updater, then it could cause widespread problems. Just thought Adobe should know.
Specs: OS X 10.6.8, MacPro 2.8 Quad-Core Xeons, Using CS6 Suite
Related thread over in Photoshop forums: