I have a Captivate quiz that is 800X600 and have published it with Scalable HTML Content selected.
If I have the window maximized greater than the original 800X600, only parts of the screen will allow me to advance when I want to continue. Each quiz slide in the project has a different area that you can click. Each time I visit the same quiz slide on another attempt, the area I can click to advance is different than the last time I attempted that question.
It's almost like the 800X600 clickable area is randomly spread around the newer, larger sized window.
Personally, I'm rather fond of avoiding the "click anywhere" and prefer to configure the caption to say "Click here to continue".
Perhaps consider trying that and see if it makes a difference?
Cheers... Rick