I went ahead and checked out your webservice address
https://ws.ruk1.net/webservices/ResponsysWS?wsdl
On the bottom of the page, you will see the
<wsdlsoap:address> location tag, and it says:
<wsdlsoap:address location="
http://ws.ruk1.net/webservices/ResponsysWS"
/>
Notice that you are requesting on normal 'HTTP' protocol, and
not 'HTTPS'. Correct that and see what happens.
HTH.