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I've recently reinstalled Photoshop CC on my Windows 10 Pro PC, and after working a bit with it, I noticed a strange problem.
After the first 20 actions (selection, brush strockes, etc), any line that I draw with any tool looks jagged or stepped. Every curve drawing tool from Lasso, including all brushes, to Clone and Blur tools are affected by this issue.
No matter if I connect the pen tablet or just use the mouse, they produce the same lines. This doesn't occur anywhere else (Animate draws lines just fine), so I don't think it is a mouse or pen tablet problem.
My guess is that there could be a conflict with my two graphic cards, a high-end Nvidia GTX 980 and a mid-end Nvidia GT 710, but I haven't tested out with just one of them. Could this be the issue?
It seems that this only happens while slices are visible. After hiding the slices I made, Photoshop was able to draw smooth curves again.
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If you have two different enabled GPUs in you system Photoshop may have problems has been posted many times. I would also think that system interrupts and conflicts could interrupt interfere with time sensitive real-time execution brush strokes require. Brush spacing and speed of stroke can also play a part.
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It seems that this only happens while slices are visible. After hiding the slices I made, Photoshop was able to draw smooth curves again.
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You may also see thing like that when you have layers and guides and snap to on and use a brush