Creative Suite applications were not designed to run or install under macOS 10.12 (Sierra). Because of this the installers may not function normally under macOS 10.12 or later.
When attempting to begin an installation of Creative Suite you may encounter the following errors:
Creative Suite 6
Installer failed to initialize. This could be due to a missing file. Please download Adobe Support Advisor to detect the problem.
Creative Suite 5 and 5.5
“Install” can’t be opened. You should eject the disk image.
Creative Suite 4
This software cannot be installed because the file system of the Setup volume is not supported.
These errors will prevent you from beginning the installation process. If you are receiving one of these errors, and are not using macOS 10.12 or later. Then the workaround below does not apply to you. Please review the installation log files to determine why the installation is failing to occur:
If you have macOS 10.12, or later, installed then please see Installing Creative Suite on macOS 10.12 (Sierra) for details regarding the workaround to allow Creative Suite installation process to begin.
If you are using macOS 10.12 or later and you continue to receive errors, after completing the workaround discussed in Installing Creative Suite on macOS 10.12 (Sierra), then review the relevant installation log files to determine what additional errors are preventing the installation.
For more details on how to review Creative Suite installation logs see FAQ’s for Creative Suite - Installation Failed and Launch errors:.
For further details on how to install Adobe applications see How to download, install, and activate Adobe applications.
read for more information https://forums.adobe.com/thread/2458382
If the above doesn't help, I don't know of anything else that can be done to try and fix the problem of Apple not maintaining backward compatibility when changing their operating system
Adobe has not changed CS6 (or earlier) programs... Apple changed