Depends on what you need to do exactly but FCKEditor has
support for passing configuration settings into the editor, like
this:
<cfset config = StructNew()>
<cfset config.ImageBrowserURL = "my_custom_URL">
<cfmodule template="customtags/fckeditor/fckeditor.cfm"
instanceName="MyField"
height="500"
config="#config#"
Value="#PreviousText#"
/>
You can set configuration variables in a similar manner if
you are calling it as a component, the cfm examples included in the
download show that method as well.