Can I safely delete Adobe\AdobePatchFiles ?

Hi!

Because my free space on one of my drives was noticeably shrinking without knowing I did install anything new on that drive I did analyze the drive folders and found this folder which is quite big:

F:\Adobe\Adobe\AdobePatchFiles\

Over 400MB.

I would like to know if I can recover the free space by deleting this folder, because I really don't want to lose free space on a hard drive without that I self install a new software or copy new files there. Following the hardware requirements the CS suite declared certain free disk space for hardware requirement of a new installation. But from this it looks that the free disk space requirement is unlimited as the AdobePatchFiles folder seems to constantly grow!! How does the CS software handle situation when the free space drops to zero due to AdobePatchFiles overbloating?