Yes and no.
The default layout has changed, and there are now editing keyboards specifically designed for the new layout. However, in the keyboard shortcuts menu, there is an option to return them to the old 5.5 and previous mappings.
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I was struggling with the CS6 kb shortcuts and they were also rendering my Logic Keyboard redundant ( mismatch).
I also lost my carefully set up custom kb settings.
Instead of retraining my brain...I imported my CS5.5 kb Custom presets and now use them in CS6.
BTW - The option to switch to CS5 KB settings inside CS6 did not seem to match what I thought were the same as the un customised originals.
I prefer the logic of FCP keyboard shortcuts. So I bought and use the FCP Logic Keyboard ( with minor variations where needed).
Thanks for the input Jim Simon and Shooternz! Between you two, I got all the answers I needed!