Anything particular about the file (size, bit depth, …)?
Are Photoshop and OS fully updated and have you performed the usual trouble-shooting routines (trashing prefs by keeping command-alt-shift/ctrl-alt-shift pressed while starting Photoshop after making sure all customized presets like Actions, Patterns, Brushes etc. have been saved and making a note of the Preferences you’ve changed, 3rd party plug-ins deactivation, system maintenance, cleaning caches, font validation, etc.)?
CS6 Lighting Effect Filter absolutly need a supported GPU Video Card with known working Video drivers without known issues. Begin by checking if your video card has the required memory has been tested by Adobe and your using drivers known to be working.
I have a NVIDIA GT-545 GPU with the latest driver. All I have to do is make one move of the lighting effects tool and click on preview and Photoshop shuts down.