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[Moved the thread to Photoshop General Discussion forum]
The safest thing to do in these cases is to get the latest software from the website itself, in case it's more recent than the software on the CD. Go to this page:
There's a long list of software there that claims to be compatible with the latest versions of OS X. Epson isn't very good at telling you which ones are important. You should install them all, but the most important ones are the Scanner Driver and EPSON Scan Utility so that you can do scans (this might also let you scan from inside Photoshop, I'm not sure), and the ICA Scanner Driver v5.3.0 for Image Capture (this lets you scan using the Apple Image Capture utility).
I don't think you have to install Photoshop Elements. The only reason to be concerned about a compatibility issue is if you wanted to scan from inside Photoshop CS6 itself. If you scan using a separate utility, as long as it saves standard formats like TIFF, PSD, or JPEG you will be able to open those scans in Photoshop CS6. So whether or not the scanning software is directly compatible with Photoshop CS6, you can still scan using the Epson or Apple utilities and open the saved scans in Photoshop CS6.
Thank you. I installed just the Epson CD and everything seem to be working fine.