This question was posted in response to the following article: http://help.adobe.com/en_US/aftereffects/cs/using/WSB8DDC87E-577E-4099-A5D0-B266E9543E09a. html
How do I turn of all anti-aliasing on the After Effects User Interface within Mac OSX? I've got LCD Font Smoothing turned off in the System Preferences > General, and increased the minimum size of smoothing to above 12 points, and think that the interface fonts are surely smaller than 12 points, but they're still being anti-aliased.
For me, and I might be alone in this, I really like clear, pixel edged fonts, and this is especially true on the new Retina Macbook Pro when running in native 2800x1800 mode.