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in addition to all the advice above:
- Avoid useless animation. Excessive animation not only adds to your Web page's download time, but many users find it distracting.
- GIF images with large blocks of solid color and horizontal patterns compress better than images with color gradations, soft shadows, and vertical patterns.
- When reducing colors in GIFs, you'll get the best compression when the number colors is set to the smallest possible of these options: 2, 4, 8, 16, 32, 64, 128, or 256.