bumping this... got the same problem still over a year later.
Same problem here - installed some OTF fonts and cfdocument PDF generation is failing with the NullPointerException as described by the OP.
Running CF 10 HF 15 / Java 1.8.45 / Windows Server 2012
Worked around it by converting the OTF fonts to TTF using FontForge. Thanks to https://webmonkeyswithlaserbeams.wordpress.com/2009/04/29/custom-fonts-in-coldfusion for the tip.