I am using Photoshop CS6 13.0.1 x64 and I can't seem to get the settings for a new document to stick.
When I make a new document my color profile never matches my color settings (RGB: Adobe RGB (1998); CMYK: U.S. Sheetfed Coated v2; Convert to Working RGB; Convert to Working CMYK; Ask when opening), it always is reset to sRGB. Also, when I create a new document it doesn't seem to remember either what I used last or what is in my clipboard - it always resets to 1 x 67.
Is there some hidden setting I'm missing?
Short standard answer: If prefs don't stick, you have permissions issues. Verify your user privileges and file permissions on the prefs folder.