Is this when using the Kuler desktop app?
I'm having a very similar issue and hope that this thread is still alive.
I'm on a Mac, OS 10.7.5, CS6.
I went to kuler.adobe.com and was quickly able to find a great theme.
I signed in with my Adobe ID, made some slight alterations to the color values.
Then I clicked the Save symbol and got a "kuler klash". My alterations were lost and I was back to a static version of the same theme. However I was unable to get back to any interaction screen I had been to seconds before. There were no interface buttons for saving or changing theme, etc. I had to do another search to bring Kuler out of this "sleep".
Can someone direct me to a solution?