This question was posted in response to the following article: http://help.adobe.com/en_US/flashbuilder/using/WSe4e4b720da9dedb5-15a3a08712e93a1ff8e-8000 .html
Attempts to make one Run/Debug configuration the default for the keyboard shortcut launch have failed. Of my emulator, iPad, and Android "Movile Application" configs, even placing the emulator as the top item in my "Organize Favorites" list, it will still run the Android config when the keyboard shortcut keys are pressed. Hopes of changing this by altering the names to have alphabetic precedence do not work either. Nothing regarding run-config in the manifest.