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In terms of visual page design I don't know of anything, but you should of course ensure the files are accessible to screen readers etc. and Acrobat has tools to verify compliance with the various standards (e.g. s508).
Although a landscape page format seems the logical choice for screen display it may not be. With the increased use of smaller-screen devices many users view PDF pages in "fit width" mode, and you can zoom in closer to a portrait page like that.