Scott Any warmings or errors in CF10\cfusion\logs\ coldfusion-out.log or -event.log when CF10 starts while Java points to 7 versa 6?
CF does not support Java 7 yet however Adobe say 7 will be supported before 6 EOL which has been pushed back from Nov 2012 to Feb 2013.
There are no errors in the coldfusion-out.log or the event log.
Check the Windows Server logs (application and system) to see if there are any conflicts on the OS.
ColdFusion10\cfusion\bin>cfstart.bat what happens when you try start CF10 from DOS CMD prompt with CF10 set to use Java 7 versa Java 6?