I updated OS X 10.7.5 to 10.8.2 and it still won't open. And yes, permissions were repaired, disk utility run from startup disc, etc.
I completely uninstalled all of Creative Suite CS6 and reinstalled and Dreamweaver STILL won't open! :-(
Well, I always seem to come up with questions that stump the crowd and have to figure these things out for myself in the end, which I did.
I logged in as root user (any alternative administrator account would work), and succesfully opened dreamweaver. I then copied all the preferences and support files to the main hard drive, where I retrieved them when I logged back into my user account. I then transferred those files to their respective places in the Library and Dreamweaver is now working again.