OK so I hope I can explain this OK.
I needed my HD changed by Apple. So I cloned my drive twice (2 full backups).
Once I cloned the drive back to the newly installed drive everything seemed OK until I opened Dreamweaver. When the "welcome screen" opens up I click on index.html for one of my sites ( I run 3 ) and it shows the path to it and says it's "not found" well I double checked the exact path it lists and the file is there.
So I figure no problem I will just use Open and I opened the index file, made my changes, saved and when to go "Put" but it's grayed out. I clicked "Manage Sites" and all my sites are listed.
So after searching I thought it was a bad site file, I restored it from another backup (Macintosh HD:Users:<username>:Library:Application Support:Adobe:Common:11:Sites:Site Prefs)
But still same thing.
I need some serious help as I need to modify my sites a few times a week. I just don't know what I am missing. Everything is where it should be but Dreamweaver acts like it's not.
Sounds like your site definition settings got corrupted.
Re-create them with Site > Manage Sites.
OK, got it fixed. Even though it said it was pointed to the correct directory in "local site folder" I picked it again and then it said something like "rebuilding cache". and it worked.