Any clues as to what's going wrong?
Bridge often gets in trouble on a network environment.
First restart Bridge holding down option key and choose reset preferences (sets preferences back to default so you have to reset custom settings).
And maybe deleting the plist file for Photodownloader also will help you.
Quit Bridge and Photodownloader an go to the user library (by default hidden per OS10.7, use menu go and press option to reveal this library)
user (your name) / library / Preferences / find and manual delete the Photodownloader plist file (com.adobe.photodownloader.plist) and try again (it will refresh itself after restarting photodownloader, but you need to reset your custom settings.
Seems odd that the only times I reboot my mac are to refresh Flash and now Photoshop
I always understood that rebooting computers was a good thing to do, refreshing a lot of stuff (and in case of overnight put it to rest, saves energy and causes less wear), Personally I have set my computer to auto shut down after finishing Back up (at my command when ready in using my Mac) and auto start up on a timer base and meanwhile as one of the first automated tasks to run the auto pilot of the Cocktail script for maintenance (clearing caches and repairing permissions etc.)
I really think this keeps my Mac in a healthy state instead of letting it run day and night, And regarding to myself, a good night sleep and a nice breakfast gives me a good start also