I recently updated my adobe software and I am still getting issues with saving layered files. I keep gettting program error - only occasionally. Sometimes saving to my desktop works and other times it doesnt. Other coworkers are experiencing same thing ever since they updated. It happens when working on a layered file for any length of time and need to save it out as a layered photoshop file. We are forced to flatten and save as a tif and loose our layers. I think it has something to do with background task but not sure...
Drag the file to your desktop, open the file there, do your edits, save, and then drag back.
Let us know what you are working off. If server, what server software are you using. System preferences >> spotlight, uncheck all items.
I have tried dragging to my desktop but occationally it still happens.