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In principle it's possible, but it wouldn't make much sense because these
libraries are written to work with JS in HTML pages, not PDF files, and the
objects, events and methods of the two are completely different (except for
core JS commands).
So yeah, you can load jQuery in Acrobat but you probably won't be able to
use any of it.
It might not work for DOM related actions, but what about some of the Ajax functions? Being able to call REST services would be really trick.