I used to use a Logitech mouse with 8 buttons. I had them each programmed to bring up a certain feature so I didn't have to use the keyboard. It worked just fine but you still had to click and drag.
There are a bunch of programmable buttons on a Wacom tablet, but it's still click and drag. To tell you the truth I've taken to just grabbing layers in the comp window for most positioning and rotating tasks. I just do it by eye. I got away from the multi button mouse because it was killing my hand. Now it's mostly a touch pad or an Apple magic mouse for me. I use a tablet occasionally in AE and a lot in Photoshop and Illustrator.