Which operating system?
Any error messages? What do they say?
Has this just started happening?
Is is a standalone version of Photoshop or part of a suite? Do you still have your CS5 serial number?
MAC OS X 10.6.8
This has been happening for a few weeks now.
There are no error messages, it just crashes and the computer goes entirely blank until I start it again.
It is part of the Adobe Creative Suite which I got a couple of years ago - I just can't find the CDs and packaging anywhere.
You could try re-installing the suite.
Provided you still have your Creative Suite CS5 serial number, you can download the trial version of the suite from
Ensure that you follow the Very Important Instructions first otherwise the links will not work.
When you launch the trial, enter your serial number and it will convert to a full version.
Why dont you try ressting the Preferences?
Run the software are Administrator and Press Shift + Alt + Ctrl while launching it, Hope this helps.