A. Fix One PC
B. Fix Several PCs in Your Organization
Following the above steps aren't practical if you have Adobe Acrobat installed on 1,000+ computers in 30 regional offices! Push this registry setting using your standard software deployment software.
When opening an attached document from an email message, or from a website, the document is usually stored on a temp folder on the local disk. Access Denied indicates a permission problem with such a temp folder.
For Outlook I found that they are stored under %userprofile%\Local Settings\Temporary Internet Files\Content.Outlook