More information needed for someone to help... please click below and provide the requested information
-Information FAQ http://forums.adobe.com/message/4200840
Read Bill Hunt on BSOD http://forums.adobe.com/thread/772169
-and an Encore fix http://forums.adobe.com/thread/1060443 which MAY help with PPro
If you mean that using Premiere Pro CS6 causes your computer to reboot - then you are looking at driver, OS, or hardware level problems.
Applications cannot cause the whole computer to shutdown, lockup, or reboot.
The most likely culprits in cases like this are bad RAM, bad GPU, bad or inadequate power supplies, bugs in drivers, and bad motherboards.