Welcome to the forum.
Will you be re-editing this material at any time? That can make a difference.
If so, I like outputting to a lossless CODEC, like Lagarith, or UT Lossless - both free. See this article: http://forums.adobe.com/message/4556586#4556586
The one drawback to such an intermediate is that the resulting file will have limited use, directly. It can be shared with others, for computer playback, but the recipient must have the same CODEC on their computer. For YouTube, Vimeo, DVD, etc., the lossless file will need to be Imported into a New Project, where it can be re-edited, but primarily to be output again, as is required for the intended delivery medium, i.e. YouTube, Vimeo, DVD-Video, etc.
For some general guidelines, see this article. Though written for PrPro, it covers all the high points for PrE: http://forums.adobe.com/thread/878590?tstart=0
As Bill implies, the answer depends on how you're going to use your output video. There is no one-size-fits-all perfect output. Different media and devices have different requirements.
It depends on how you're going to use the file and where you plan to publish it.
Thanks a lot Bill, I will have a look to your links and I will try to install the lossless codec. Rgds.